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Blog
A Journey of Hope in Pediatric Cancer Survivorship
Alexandra Paúl, MD, Medical Strategy Lead, Pediatric and Rare Disease Center of Excellence
Feb 10, 2025
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  • A Journey of Hope in Pediatric Cancer Survivorship

Advances in medical science have significantly improved the survival rates for children diagnosed with cancer, bringing hope to countless families. While survivorship rates for pediatric cancers vary by type, the average five-year survival rate has risen to approximately 85% in recent years, a remarkable increase from the mid-1970s rate of 58%.1,2 Each survivor's story shines as a beacon of light, with survivorship symbolizing a new chapter in the lives of families who have triumphed over childhood cancer.

Nevertheless, the journey through pediatric cancer is fraught with immense challenges. While the rising survivorship rates are a cause for celebration, it is crucial to recognize and address the unique challenges that long-term survivors face. Although most late effects are not life-threatening, they can still significantly impact health and quality of life. Specialized clinics, personalized survivorship care plans, and an extensive support network are being progressively strengthened to tackle these challenges and promote the well-being of survivors into adulthood.

However, beyond the physical health concerns, survivors frequently encounter significant social, cognitive, and emotional challenges that necessitate comprehensive support and care. The emotional toll of cancer and its treatment can be profound, with many survivors experiencing anxiety, depression, and post-traumatic stress, often struggling with social reintegration. Prolonged absences from school and social activities can lead to feelings of isolation and difficulty in forming and maintaining friendships, often facing stigma or misunderstanding from peers who do not fully grasp their experiences. Additionally, cancer treatments can impact cognitive functions, leading to difficulties with memory, attention, and learning, which in turn affect academic performance and overall quality of life.

Overcoming these obstacles requires a holistic approach that integrates medical, psychological, educational, and social support. A robust collaboration among healthcare professionals, educators, and families is indispensable for cultivating a supportive environment that fosters resilience and growth. This collaborative effort ensures that survivors, and their family, receive the necessary resources and encouragement to navigate their post-cancer lives, enabling them to thrive and embrace the future with hope and strength.


Pediatric cancer trials have significantly enhanced the quality of life for survivors

By advancing our understanding and treatment of cancer, continuously refining treatment protocols, and addressing the comprehensive needs of survivors, pediatric cancer trials have a profound impact on their quality of life. Advances in personalized medicine, driven by clinical trial data insights, enable treatments to be tailored to the individual characteristics of each patient’s cancer. This approach enhances treatment efficacy and reduces side effects, thereby leading to improved long-term outcomes and quality of life for survivors. Furthermore, as pediatric cancer trials progressively augment our understanding of these effects, they contribute to more efficient monitoring and management. There is an increased emphasis on developing less toxic treatments to mitigate the risk of late effects. Long-term follow-up research is also essential for gathering valuable information on the health and quality of life of survivors, pinpointing risk factors for late effects, and shaping guidelines for long-term care to guarantee that survivors receive ongoing support through adulthood.


Instruments intended to support pediatric cancer survivors:

Efforts are currently concentrated on creating and implementing specific tools in the United States and Europe to ensure survivors receive thorough and coordinated care:

  • The Survivorship Passport is an innovative digital tool currently in the process of being implemented through the PanCareSurPass EU project, designed to provide optimal long-term care for childhood cancer survivors and aiming to harmonize follow-up care across Europe, promoting consistent and evidence-based guidelines for the prevention, early detection, and treatment of late effects.
  • The Passport for Care is a similar support tool, helping survivors of childhood cancer to manage their long-term health care and providing personalized care guidelines based on the survivor's treatment history (helping healthcare providers deliver appropriate follow-up care).
  • The My Childhood Cancer Survivor Plan is a tool developed by the Children's Oncology Group (COG) in the United States, also aiming to provide personalized survivorship care plans for childhood cancer survivors. It includes detailed information about the survivor's treatment history and recommendations for follow-up care to monitor and manage late effects.

With these remarkable advances provided through clinical research, survivorship continues to epitomize the resilience and strength of young patients and their families. Hope remains an unwavering cornerstone, steadfastly guiding survivors and their families as they navigate the complex and multifaceted realities of life after cancer.

 

References

  1. https://www.cancer.org/cancer/types/cancer-in-children/key-statistics.html
  2. https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet

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