Oncology
Focus oncology development on the patient, manage trial complexity, and increase predictability and speed.
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Americas
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Asia & Oceania
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A-I
J-Z
EMEA Thought Leadership
Developing IQVIA’s positions on key trends in the pharma and life sciences industries, with a focus on EMEA.
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Middle East & Africa
EMEA Thought Leadership
Developing IQVIA’s positions on key trends in the pharma and life sciences industries, with a focus on EMEA.
Learn more
Regions
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Americas
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Asia & Oceania
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Europe
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Middle East & Africa
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Americas
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Asia & Oceania
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Europe
Europe
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EMEA Thought Leadership
Developing IQVIA’s positions on key trends in the pharma and life sciences industries, with a focus on EMEA.
Learn more -
Middle East & Africa
EMEA Thought Leadership
Developing IQVIA’s positions on key trends in the pharma and life sciences industries, with a focus on EMEA.
Learn more
SOLUTIONS
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Research & Development
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Real World Evidence
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Technologies
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THERAPEUTIC AREAS
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Impacting People's Lives
"We strive to help improve outcomes and create a healthier, more sustainable world for people everywhere.
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Harness the power to transform clinical development
Reimagine clinical development by intelligently connecting data, technology, and analytics to optimize your trials. The result? Faster decision making and reduced risk so you can deliver life-changing therapies faster.
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Generate and disseminate evidence that answers crucial clinical, regulatory and commercial questions, enabling you to drive smarter decisions and meet your stakeholder needs with confidence.
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Orchestrate your success across the complete compliance lifecycle with best-in-class services and solutions for safety, regulatory, quality and medical information.
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Unlock your potential to drive healthcare forward
By making intelligent connections between your needs, our capabilities, and the healthcare ecosystem, we can help you be more agile, accelerate results, and improve patient outcomes.
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IQVIA AI is Healthcare-grade AI
Building on a rich history of developing AI for healthcare, IQVIA AI connects the right data, technology, and expertise to address the unique needs of healthcare. It's what we call Healthcare-grade AI.
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Your new expert analyst is here. Be at the forefront of data-driven decision-making with a new generative AI tool that enables you to interact with our products and solutions like never before. Get results you can trust, faster.
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The IQVIA Human Data Science Cloud is our unique capability designed to enable healthcare-grade analytics, tools, and data management solutions to deliver fit-for-purpose global data at scale.
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Innovations make an impact when bold ideas meet powerful partnerships
The IQVIA Innovation Hub connects start-ups with the extensive IQVIA network of assets, resources, clients, and partners. Together, we can help lead the future of healthcare with the extensive IQVIA network of assets, resources, clients, and partners.
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IQVIA Decentralized Trials deliver purpose-built clinical services and technologies that engage the right patients wherever they are. Our hybrid and fully virtual solutions have been used more than any others.
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Empowering patients to personalize their healthcare and connecting them to caregivers has the potential to change the care delivery paradigm.
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White Paper
A time for critical change
How PD-1/L1 has accelerated innovation in the oncology value chain
Apr 27, 2018
Introduction
Cancer immunotherapy, which uses the body’s natural defense against cancer, has emerged as the next generation of treatment, with checkpoint inhibitors being the first type of treatment to be approved. In particular, the CTLA-4 inhibitor ipilimumab was approved in 2011. Since then, 5 PD-1/L1 molecules have been approved: pembrolizumab (2014), nivolumab (2014), atezolizumab (2016), avelumab (2017), and durvalumab (2017).
While there are still significant unmet needs in oncology, especially for metastatic cancers, there is high hope surrounding the potentially long-lasting clinical benefit of checkpoint inhibitors in most tumor types where they have been approved. Given this, we anticipate the landscape to evolve considerably over the next 5 years. While the next wave of checkpoint inhibitors (e.g., OX40, LAG3, TIM3, IDO1, etc.) is expected to arrive in that timeframe, PD-1/L1s will likely remain the backbone of therapies, with the new checkpoint inhibitors being used in combination. These agents hold both significant promise and high uncertainty for pharmaceutical manufacturers, researchers, prescribing physicians, and patients. This white paper provides an overview of how the advent of PD-1/L1 therapies has disrupted the stakeholder value chain in oncology.