Regions
MAIN/REGIONS
regions/
Regions
  1. Americas
  2. Asia & Oceania
  3. Europe
  4. Middle East & Africa
  1. Solutions
  2. Products
  3. Insights
  4. About
  5. Careers
  6. Contact Us
MAIN/search
MAIN/Solutions
Solutions/
SOLUTIONS
  • Research & Development
  • Real World Evidence
  • Commercialization
  • Safety & Regulatory Compliance
  • Technologies
LIFE SCIENCE SEGMENTS
HEALTHCARE SEGMENTS
THERAPEUTIC AREAS

Impacting People's Lives

"We strive to help improve outcomes and create a healthier, more sustainable world for people everywhere.

LEARN MORE
Harness the power to transform clinical development

Reimagine clinical development by intelligently connecting data, technology, and analytics to optimize your trials. The result? Faster decision making and reduced risk so you can deliver life-changing therapies faster.

Research & Development Overview
Research & Development Quick Links
Real World Evidence. Real Confidence. Real Results.

Generate and disseminate evidence that answers crucial clinical, regulatory and commercial questions, enabling you to drive smarter decisions and meet your stakeholder needs with confidence.

REAL WORLD EVIDENCE OVERVIEW
Real World Evidence Quick Links
See markets more clearly. Opportunities more often.

Elevate commercial models with precision and speed using AI-driven analytics and technology that illuminate hidden insights in data.

COMMERCIALIZATION OVERVIEW
Commercialization Quick Links
Service driven. Tech-enabled. Integrated compliance.

Orchestrate your success across the complete compliance lifecycle with best-in-class services and solutions for safety, regulatory, quality and medical information.

COMPLIANCE OVERVIEW
Safety & Regulatory Compliance Quick Links
Intelligence that transforms life sciences end-to-end.

When your destination is a healthier world, making intelligent connections between data, technology, and services is your roadmap.

TECHNOLOGIES OVERVIEW
Technology Quick Links
MAIN/Products
Products/
CLINICAL PRODUCTS
COMMERCIAL PRODUCTS
COMPLIANCE, SAFETY, REG PRODUCTS
REAL WORLD PRODUCTS

CASE STUDY

"Data in a Day

LEARN MORE
MAIN/Insights
Insights/
BLOGS, WHITE PAPERS & CASE STUDIES

Explore our library of insights, thought leadership, and the latest topics & trends in healthcare.

DISCOVER INSIGHTS
THE IQVIA INSTITUTE

An in-depth exploration of the global healthcare ecosystem with timely research, insightful analysis, and scientific expertise.

SEE LATEST REPORTS

INSTITUTE REPORT

"Global Trends in R&D 2024

READ MORE

EMEA Insights

"IQVIA thought leadership with a focus on EMEA.

Learn more

WHITE PAPER

"DCTs Deliver Big ROI

LEARN MORE

WHITE PAPER

"Capturing value at scale: The $4 billion RWE imperative

LEARN MORE
MAIN/About
About/
FEATURED INNOVATIONS
  • IQVIA Connected Intelligence™
  • IQVIA Healthcare-grade AI™
  • Human Data Science Cloud
  • IQVIA Innovation Hub
  • Decentralized Trials
  • Patient Experience Solutions with Apple devices
WHO WE ARE
NEWS & RESOURCES

INVESTOR RELATIONS

"Visit our investor relations site for more information.

LEARN MORE
Unlock your potential to drive healthcare forward

By making intelligent connections between your needs, our capabilities, and the healthcare ecosystem, we can help you be more agile, accelerate results, and improve patient outcomes.

LEARN MORE
IQVIA AI is Healthcare-grade AI

Building on a rich history of developing AI for healthcare, IQVIA AI connects the right data, technology, and expertise to address the unique needs of healthcare. It's what we call Healthcare-grade AI.

LEARN MORE
Your healthcare data deserves more than just a cloud.

The IQVIA Human Data Science Cloud is our unique capability designed to enable healthcare-grade analytics, tools, and data management solutions to deliver fit-for-purpose global data at scale.

LEARN MORE
Innovations make an impact when bold ideas meet powerful partnerships

The IQVIA Innovation Hub connects start-ups with the extensive IQVIA network of assets, resources, clients, and partners. Together, we can help lead the future of healthcare with the extensive IQVIA network of assets, resources, clients, and partners.

LEARN MORE
Proven, faster DCT solutions

IQVIA Decentralized Trials deliver purpose-built clinical services and technologies that engage the right patients wherever they are. Our hybrid and fully virtual solutions have been used more than any others.

LEARN MORE
IQVIA Patient Experience Solutions with Apple devices

Empowering patients to personalize their healthcare and connecting them to caregivers has the potential to change the care delivery paradigm.

LEARN MORE
MAIN/Careers
Careers/
WORKING AT IQVIA

Our mission is to accelerate innovation for a healthier world. Together, we can solve customer challenges and improve patient lives.

LEARN MORE
LIFE AT IQVIA

Careers, culture and everything in between. Find out what’s going on right here, right now.

LEARN MORE

WE’RE HIRING

"Improving human health requires brave thinkers who are willing to explore new ideas and build on successes. Unleash your potential with us.

SEARCH JOBS
MAIN/Contact Us
Contact Us/
Blog
Advancing Clinical Trials: A Deep Dive into Bayesian Interval-Based Designs for Phase I Dose-Escalation Trials
Ayon Mukherjee, C.Stat, Director and Head of Novel Trial Design Methodology, Regulatory Affairs and Drug Development Solutions (RADDS)
Jun 28, 2024
  • Blogs
  • Advancing Clinical Trials: A Deep Dive into Bayesian Interval-Based Designs for Phase I Dose-Escalation Trials

As a global provider of advanced analytics, technology solutions, and contract research services to the life sciences industry, IQVIA is always at the forefront of leveraging cutting-edge methodologies for clinical research. In line with this commitment, we are pleased to share our latest joint research paper titled "Bayesian Interval-Based Designs for Phase I Dose-Escalation Trials: A Case Study in Oncology."

The objective of Phase I trials is to determine the maximum tolerated dose (MTD) or optimal biological dose (OBD) of a new drug. With the advent of novel molecular therapies, the FDA's Project Optimus initiative has highlighted the need to consider the efficacy of a drug in relation to dosage rather than focusing on the MTD alone.

Our joint research explores the potential of Bayesian interval-based designs, in addressing these challenges. This approach uses probabilistic models and prior knowledge to adaptively adjust dosage levels, enabling a more precise estimation of the OBD.

However, our research goes a step further by using a real-life case study to demonstrate the efficiency of a modified BOIN12 design that combines toxicity information with efficacy rates. This modified approach is shown to be better suited for trials with a benign toxicity profile, aligning perfectly with the objectives of Project Optimus.

In addition to the theoretical benefits, our research also delved into the practical considerations for implementing Bayesian interval-based designs for dose optimization in real-world trials. We discussed several factors including determining priors, handling late-onset toxicities, and managing dropouts, thereby offering valuable insights for trialists.

This research is a significant stride towards enhancing the efficiency and ethical conduct of Phase I dose-escalation trials by considering the patients’ benefit/risk profile. It will have a profound impact on the development and approval of new oncology treatments.

At IQVIA, we are committed to innovation and the application of advanced methodologies that can accelerate the process of bringing new treatments to market. Our exploration of Bayesian interval-based designs for dose optimization underscores this commitment.

We invite you to examine this research in detail here: https://www.longdom.org/open-access/bayesian-interval-based-designs-for-phase-i-doseescalation-trials-a-case-study-in-oncology.pdf

You may also be interested in

Fact Sheet
IQVIA Trial Manager Fact Sheet
Fact Sheet
IQVIA Trial Manager Fact Sheet
Podcast
Revolutionizing the clinical trial patient experience
White Paper
Dose-Finding in Early Clinical Trials with IQVIA Trial Designer
Institute Report
Global Trends in R&D 2023
Institute Report
Global Trends in R&D 2022
Prev
Next

Related solutions

Regulatory Compliance

Automate and standardize your regulatory management, from correspondence and commitments to registration and tracking.

Safety & Regulatory Compliance

Meet the challenge of changing stakeholder demands and increasing cost constraints with IQVIA's integrated technology services and analytics-driven offerings.

Contact Us